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Moreover, to determine how the lack of IGF1R in the lung TME is mechanistically affecting tumor growth and metastasis, we performed double fluorescence immunostainings of p-IGF1R with CD31 (vascularization), Vimentin (fibroblast presence) and SMA (fibroblast activation) in lung sections from LLC-challenged mice

The co-administration of drugs reduces mortality but also introduces more drugdrug interactions and increases the risk of developing immune reconstitution inflammatory syndrome (IRIS) [66]