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Apart from human studies, mice with heterozygous and homozygous mutation in Mthfr C677T still accompany with global DNA hypomethylation, decreased SAM and increased SAH levels 41

doi: 10.3389/fnmol.2019.00204, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 16.Szutowicz A, Bielarczyk H, Zyk M, Dy A, Ronowska A, Gul-Hinc S, et al