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Nonmedical use of the drug increases the odds and severity of negative effects
Ueland T, Svardal A, ie E, Askevold ET, Nymoen SH, Bjrndal B, Dahl CP, Gullestad L, Berge RK, Aukrust P: Disturbed carnitine regulation in chronic heart failureincreased plasma levels of palmitoyl-carnitine are associated with poor prognosis
Neurotoxicology 30:10001007
However, safety depends on several factors: injection site rotation to avoid lipodystrophy, adequate hydration (both agents can increase fluid demand), and monitoring of B vitamin status since semaglutide may affect nutrient absorption slightly during rapid weight loss phases
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