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In diabetic state, hyperglycemia leads to overproduction of free radicals (i.e., mitochondrial , NO and peroxynitrite) mainly derived from glucose oxidation and lipid peroxidation, which cause oxidative damage to biomolecules

Journal of Molecular Medicine, 2017

[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Woods SC, Lutz TA, Geary N, Langhans W

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For individuals with a diagnosed B12 deficiency or impaired absorption, the dosage for B12 injections is significantly higher to replenish stores and manage symptoms