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4: MOTS-c Proposed use: Obesity and osteoporosis Proposed forms: Subcutaneous injection No

Counsel that GI side effects during the dose-escalation phase (weeks 0 to 24) may transiently suppress libido

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However, the clinical evidence base remains preliminary, heterogeneous, and limited in size, with several trials not primarily powered to detect addiction-related outcomes

Samples were then amplified and sequenced on a NextSeq 500 system (Illumina), where an average of 30 million reads were generated from each sample