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1), where the patient's own ultrafiltrated fluid is regenerated and subsequently re-infused into the patient's blood, avoiding direct contact between the blood cells and the adsorbent material, thus overcoming the tolerability and problems of blood coagulation initially observed with HP.29 The purpose of this review is twofold: firstly, to analyze, synthesize and discuss the evidence accumulated in recent years on the use of HFR, and secondly, as a consensus panel of nephrologists with clinical experience with this dialysis modality, to summarize our points of view on how to use this technique and in which patient profile it is especially indicated, offering the clinician a practical vision when prescribing and monitoring this technique in his or her clinical activity