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In high-fat diet-induced obese murine models, semaglutide reduced expression of fibrotic genes including collagen type I alpha 1 (COL1A1), COL6A3, and LOX, an effect partly attributed to activation of AMP-activated protein kinase (AMPK) and downstream SIRT1/PGC-1 pathways, which repress profibrotic transcriptional regulators [11,14]