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Abbreviations: methionine (Met), S-adenosylmethionine (S-Ado-Met), S-adenosylhomocysteine (S-Ado-HCys), homocysteine (HCys), methionine adenosyltransferase (MAT), S-adenosylhomocysteine hydrolase (AHCY), DNA- methyltransferases (DNMTs)

10.1016/j.jtbi.2005.07.003

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Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice

In fact, it has been shown that the translation of senescence chondrocytes in mice knee joint resulted in OA phenotype, characterized by leg pain, impaired mobility, and radiographic and histological changes (Xu et al., 2017)