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4 The hypothesized mechanism of gut microbiome dysbiosis in NIU 4.1 Increased intestinal permeability and gut microbial translocation Alterations in the gut microbiome may affect intestinal permeability and lead to leaky gut, which would allow the translocation of gut microbes and their products into the systemic circulation, thereby triggering innate and/or adaptive immune responses

Its getting depleted because of excessive usage

If that's the reason

Yeast infections, particularly vulvovaginal candidiasis and candidal balanitis, are not listed as recognized adverse effects specific to these medications in clinical trials or post-marketing surveillance data

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