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Because accurate determination of the NADPH consumption rate can be confounded by the reduction rate of NADP + , we inhibited key biochemical pathways that reduce NADP + back to NADPH in LPS-stimulated Ms, including glucose-6-phosphate dehydrogenase (G6PD), isocitrate dehydrogenases and folate-mediated one carbon metabolism that can contribute to the reduction of NADP + [1820]

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encoded by the ABCC2 gene) and the breast cancer resistance protein (BCRP

Dampened ER stress signaling was also evident from diminishment of the splicing of the IRE1 nuclease target Xbp1 (Figure 1B) and of the upregulation of the stress-regulated factor CHOP (Figure 1C)

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