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Journal of Medicinal Chemistry, 58 (18), 7370-7380

Data were collected from a 20-week pilot trial (NCT05786521), which randomized 20 older adults (72.7 4.8 years of age, 50% women, 45% Hispanic) living with prediabetes/diabetes (hemoglobin A1C 5.7%7.5%) and overweight/obesity [body mass index (BMI): 32.9 4.0 kg/m 2 ] to 1.0 mg/weekly semaglutide + lifestyle counseling (n = 10) or lifestyle counseling alone (n = 10)

To in vitro tests, human venous blood was collected from healthy volunteers that signed the Informed Consent Form (ICF)