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Badania na modelach zwierzcych sugeruj efekty anksjolityczne i przeciwdepresyjne, prawdopodobnie mediowane przez interakcj z ukadem dopaminergicznym i serotoninergicznym

Conclusion Intraventricular administration of streptozotocin (3 mg/kg, single bilateral injection) induces not only neuronal damage but also reactive astroglial changes, pronounced tanycyte degeneration, disruption of the ependymal lining in the third and lateral ventricles, astrocytic dysfunction, and altered distribution of aquaporin-4 and connexin-43 in hypothalamic structures

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