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This distinction suggests that pyroptosis may represent a more prioritized therapeutic target in the early or acute stages of disease, whereas ferroptosis inhibition strategies may hold unique value in the chronic phase or in patients with comorbid conditions such as iron overload or diabetes
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(181) established a high-iron diet mouse model, demonstrating that iron overload significantly increases iron levels in serum, colonic tissue, and feces, and successfully induces colitis phenotypes and ferroptosis
Common Adverse Effects According to pharmaceutical research on semaglutide, gastrointestinal effects are most frequent: nausea (20-44% incidence, usually mild-moderate, improves over time), vomiting (9-24% incidence), diarrhea (20-30% incidence), constipation (20-24% incidence), and abdominal pain (8-20% incidence)
