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Key Characteristics & Symptoms Individuals with PWS may experience a combination of physical, behavioral, and metabolic symptoms: Physical Features Almond-shaped eyes Narrow bridge of the nose Short stature Small hands and feet Thin upper lip & downturned mouth corners Scoliosis Obesity (due to relentless appetite) Behavioral & Cognitive Features Hyperphagia (uncontrolled hunger) Learning difficulties Low muscle tone in infancy Temper outbursts Obsessive-compulsive behaviors Low impulse control Risk of psychosis in adolescence/adulthood Hormonal Abnormalities Hypogonadism Delayed or incomplete puberty Low growth hormone Reduced metabolic rate Diagnosis Diagnosis is typically confirmed through genetic testing , including: Methylation analysis FISH (fluorescent in situ hybridization) Microarray Early testing is essential for prompt intervention

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Interestingly, while inhibition of MEK by PD98059 effectively suppressed ERK1/2 activation, reduced p-ERK1/2 expression levels, and alleviated the EMT process, TB001 did not affect ERK1/2 signaling pathway ( Figure 8E ), aligning with the immunohistochemistry results in kidney grafts