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At doses six times greater than its efficacious dose (60 mg/kg, PO), 710GO did not cause changes in telemeterized NHPs to any of the measured cardiac parameters, including systolic blood pressure, diastolic blood pressure, heart rate, and corrected QT interval (25)

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Upregulation of caveolin-1 contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats

Pregnant or breastfeeding women should consult their healthcare provider before use, as safety in these groups has not been established