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doi: 10.1016/0306-4522(83)90152-5

Cardiometabolic outcome trials Pooled analysis of Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 1-5 (assessing semaglutide at lower doses of 0.5 and 1 mg doses for the treatment of T2D), found semaglutide had a similar weight reduction, and glycaemic control, efficacy in older and younger adults

The 28% average body weight reduction observed in retatrutides Phase 3 programme, alongside an 82.4% reduction in liver fat in MASLD participants, positions it as the most potent incretin-based compound currently in late-stage development [2][4]