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*Correspondence: Zhigang Ren [email protected] Yu [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This protective effect involves TUG1 binding to the RNA splicing factor 1, which stabilizes ACSL4 mRNA- a key driver of lipid peroxidation- highlighting a novel axis for therapeutic intervention

The lysosomal destabilization and cathepsin B release to the cytosol has been confirmed in a murine in vivo model as well as in human MASLD (Feldstein et al

Human studies are promising, but not yet definitive for lifespan extension

Local Reactions: Injection Site Reactions : Mild irritation, redness, or swelling at the subcutaneous injection site