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Lilly's Zepbound (tirzepatide) superior to Wegovy (semaglutide) in head-to-head trial showing an average weight loss of 20.2% vs

Any early weight changes may be attributed to: Reduced caloric intake due to appetite suppression Decreased fluid retention in some individuals Changes in glycogen stores and associated water weight Reduced food volume in the digestive system It is important to understand that week one weight changes are not indicative of long-term results

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During weight gain, skin stretches to accommodate increased volume