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Subgroup analyses by geographic region, metabolic status, background diet, and intervention type have been inconsistently reported, and where conducted, frequently lacked statistical power due to small subgroup sample sizes

We identify a critical gap in the field: although over 103 phenolic compounds have been documented, many reports lack methodological standardization, quantitative reproducibility, and chemometric alignment, limiting their comparability and downstream industrial translation

Hypersensitivity to the drug or any of its components