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For Part D plan sponsors, the orphan drug exemption from negotiation could be a double-edged sword: on one hand, it preserves manufacturer revenues (and thus perhaps maintains broad drug availability), but it also means plans wont benefit from negotiated lower costs on some high-priced drugs, which could keep Part D spending (and premiums) higher than otherwise

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"Treatment includes a diet low in phenylalanine through eliminating some foods with protein, so L-tyrosine supplements play an important role

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