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The primary outcome of Study 023 was the proportion of pivotal patients aged greater than or equal to 12 years at baseline who were treated with setmelanotide for approximately 52 weeks and achieved a greater than or equal to 10% reduction in body weight, as measured from the active treatment baseline

Three mechanisms compound

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demonstrated that metronidazole monotherapy administered two weeks before disease induction significantly attenuated EAU severity, further supporting its role as a prophylactic agent through early intervention (132)