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This margin of safety provides reassurance, though caution remains appropriate given the limited formal human studies

A: Primarily studied for fat metabolism, lipolysis stimulation, and lipogenesis inhibition

These medical-grade patches follow a 12-hour wear cycle during an initial 3-day loading phase, transitioning to a once-daily maintenance schedule (12 hours on, 12 hours off) to sustain benefits

Immune tolerance mechanisms, including central tolerance in the thymus and peripheral tolerance in secondary lymphoid organs, are essential for preventing autoimmunity [139, 140]