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Advances of targeting the YAP/TAZ-TEAD complex in the hippo pathway for the treatment of cancers

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The American Diabetes Association and European Association for the study of Diabetes consensus guideline recommends that, in people with type 2 diabetes and established atherosclerotic cardiovascular disease, treatment for hyperglycaemia should be diet, lifestyle change and metformin, followed by, if this does not achieve target HbA 1c levels, an agent proven to reduce cardiovascular mortality risk (Davies, 2018)

Forming some new blood vessels is good for healing wounds, but uncontrolled vessel growth can be problematic