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It evolves through a continuum of biochemical alterations that often precede overt clinical disease by several years

Vitamin B6 (pyridoxine) at doses of 1025 mg three times daily has demonstrated anti-nausea effects and is generally well-tolerated, though patients should not exceed 100 mg daily due to risk of peripheral neuropathy with long-term high doses

This stroke also causes irreversible loss of vision in one eye. The ninth patient developed swelling in both optic nerves but did not lose vision, Katz added

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