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Balhara B, Misra M, Levitsky LL: Recombinant human IGF-1 (insulin-like growth factor) therapy: where do we stand today

Sirtuins utilize NAD + to catalyze deacetylation and ADP-ribosylation reactions, thereby modulating gene expression, metabolism, and stress resistance in a manner tightly linked to cellular NAD + availability

But, chronic inflammation has been linked to cardiovascular disease, autoimmune disease, gastrointestinal disorders, and mental illness

Gelatin Capsules: Standard gelatin is frequently made from porcine sources

This offers a compelling mechanistic rationale for their use in DR, suggesting they do not merely offer a generic anti-inflammatory benefit, but may directly intervene in the specific immunological events now known to perpetuate retinal damage