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Toll-like receptor 4 (TLR4) is a crucial component in the stress response, activating the immune system using pathogen-like mechanisms to induce an inflammatory response, and TLR4 is expressed in various cells, including microglia, astrocytes, and neurons

Nevertheless, pathways implicated in preclinical studies, including angiogenesis, inflammatory modulation, and collagen remodeling, intersect with biologic systems central to incision healing and complication avoidance, although these mechanistic signals have not been shown to translate into improved clinical outcomes

(4) Nanoparaquat group: received nanoparaquat equivalent to a dose of 4 mg/kg PQ intraperitoneally injected for one week

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