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IL-8 is a powerful neutrophil attractant, and is one of the major mediators of the inflammatory response

Dosage is incremented in steps over weeks, based on the body's reaction

Therapeutically, p53 activation dualistically regulates apoptosis and ferroptosis to suppress PCa growth, but ferroptosis-driven macrophage polarization in the TME may inadvertently promote tumor metastasis [Figure 2A], emphasizing the need for context-specific modulation to balance efficacy and paradoxical outcomes

2017 Dec 12 2 Katz JN, Zimmerman ZE, Mass H, Makhni MC

Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes