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As a result, folate deficiency can lead to many neuropsychiatric manifestations, such as depression, alterations in neurotransmitter function, DNA damage, as well as being associated with the development of autism spectrum disorders in children, neural tube irregularity and brain development defects (, , , , , , , )

If an adverse effect, or even the inconvenience, of a particular therapy outweighs the benefits for the patient, then it might not be worthwhile to include it in a management strategy

Most of the drugs scavenged free radicals ( n = 25) while a subset chelated Fe 2+ ( n = 6) and inhibited 15-LOX ( n = 6)

doi: 10.1111/jpi.12748 52 MoradkhaniFMoloudizargariMFallahMAsghariNHeidari KhoeiHAsghariMH