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This process, called central sensitization, involves neuroinflammation, specifically activation of microglial cells in the brain and spinal cord

17:16121632 Sikiric P, Seiwerth S, Rucman R et al (2013) Toxicity by NSAIDs

Cagrilintide showed similar directional improvements, though the magnitude was generally proportional to the degree of weight loss rather than suggesting independent cardiovascular effects

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