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NAD+ levels fall ~50% between young adulthood and age 60 due to increased CD38 expression (which degrades NAD+) and accumulating DNA damage that depletes pools via PARP activity

Notably, although there was not a statistically significant increase in biliary disease among GLP-1 receptor agonist users in this study, the FDA 2 added warnings and precautions about acute cholecystitis and biliary disease to the label in late 2022 based on data from placebo-controlled RCTs as well as other observational data 3

FOXO4-DRI, intended for research use only, has the potential to take the industry to a new level

Clinical trials of Foundayo (orforglipron) reported average A1C reductions ranging from about 1.2% to 1.7% depending on the dose, with many participants reaching target A1C levels below 7%

But overall point I am getting at is when things are prescribed fast and loose, it doesnt just create patient risk, it puts the entire industry at risk