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doi: 59

The new drugs, which were originally developed to treat diabetes, are targeting the biology that makes weight so hard to lose and keep off: They dial down hunger in the brain, slow gastric emptying, and improve post-meal insulin signaling

El Manira A, Kyriakatos A

Levels of plasminogen activator inhibitor-1 (PAI-1) and tPA antigens were determined by ELISAs (Hyphen BioMed, Neuville-Sur-Oise, France), while PAI-1 activity was evaluated using a chromogenic assay (Chromolize PAI-1, Trinity Biotech, County Wicklow, Ireland)