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Example: One patient from Arizona came to us because, despite being maximized on treatment for Rheumatoid arthritis with DMARDs and a biologic, her disease control was very poor

Given the importance of hyperandrogenism-hyperinsulinemia in PCOS, most of the current therapeutic strategies aim at reducing androgen excess by improving insulin sensitivity, mainly via lifestyle changes and/or pharmacological approaches

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In contrast, discontinuation of GLP-1 and GIP related drugs attenuates these effects, and the reduction in GLP-1/GIP receptor agonist activity after treatment withdrawal may lead to weight regain

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