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Nature 582 , 129133 (2020)

V., Mansutti, M., Pivot, X., et al

Mar 1 2020;155(3):243-249

3.1.3 DON DON (6-diazo-5-oxo-l-norleucine), a glutamine analog, irreversibly inhibits various glutamine utilization enzymes, such as glutaminase and glutamine synthetase, by forming covalent bonds with nucleophilic residues on the active site of the enzyme (Rajagopalan and DeBerardinis, 2011