In a rat model of hyperthyroidism induced by levothyroxine sodium, total extract and large polar iridoid fractions of Scrophulariae Radix significantly decrease key enzymes involved in glycolysis and the tricarboxylic acid cycle under hypermetabolic conditions (103)
van Praag H, Shubert T, Zhao C, Gage FH
Yadav SK, Rai SN, Singh SP
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This pathophysiological transition suggests that pharmacological restoration of the OXPHOS-glycolysis axis could serve as a novel therapeutic strategy to ameliorate age-related bioenergetic decline through metabolic reprogramming interventions