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The ability to normalize glucose metabolism before type 2 diabetes develops may alter health trajectories in ways that extend far beyond weight loss

For example, happiness, anger, sadness, or fear

While melatonin has a direct effect on oxidative stress by scavenging ROS and RNS (1), its metabolites (product of its degradation) are also active and act indirectly by inducing the production of anti-oxidative enzymes and lowering the synthesis of pro-oxidative molecules (2) leading to an overall reduction of oxidative stress

There are some mechanisms involved in GSH diminution: increased oxidation by intracellular oxidizing agents, increased conjugation to molecules, and increased exit across the cell membrane [137]

Methods: This is a case-control study, nested within a cohort study