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[1] [3] Key safety considerations include: Bleeding risk assessment : Ensure patients understand signs of bleeding (unusual bruising, blood in urine or stools, prolonged bleeding from cuts) and when to seek help Medication adherence : Address any gastrointestinal side effects promptly to prevent non-adherence to either medication Hydration status : Gastrointestinal adverse effects may cause dehydration, which can affect renal function and potentially impact DOAC clearance or increase risk of acute kidney injury Injection site management : Patients should rotate Ozempic injection sites and avoid injecting into areas with bruising or active bleeding Pancreatitis awareness : Stop Ozempic and seek urgent medical attention if severe persistent abdominal pain radiating to the back occurs Diabetic retinopathy monitoring : Particularly important in patients with pre-existing retinopathy Hypoglycaemia risk : Increased when Ozempic is used with insulin or sulfonylureas Patient education is paramount