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AOD-9604 addresses this challenge through its selective mechanism

While GLP-1 can bind to receptors on circumventricular regions (e.g., area postrema), it is yet unclear to what extent gut-derived or brain-derived GLP-1 contribute to central GLP-1R activation (Trapp & Brierley, 2022)

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It should not be used in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, and caution is advised in patients with a history of pancreatitis or gallbladder disease