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Acute treatments: Non-steroidal anti-inflammatory drugs (NSAIDs) and/or mild analgesics such as acetaminophen, sometimes combined with caffeine Triptan drugs (eg, sumatriptan, rizatriptan) Other drugs such as ergot alkaloids, opioids, and corticosteroids Preventive treatments (generally for frequent recurring migraines): Blood pressure medications Tricyclic antidepressants Anticonvulsants What Dietary and Lifestyle Changes Can Be Beneficial for Migraine Headaches