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Prior efforts to treat obesity demonstrate that sustained weight reduction is a Herculean task--thus it may be the case that GLP-1 agents will need to be administered chronically to sustain anti-obesity benefits

In populations who cannot exercise due to frailty, physical disability, or cardiovascular limitations, MOTS-c represents one of the most compelling candidates in the emerging class of pharmacological exercise mimetics

But milligram-to-milligram comparison is meaningless between these two molecules because their potencies differ

King SH, et al

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