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Apart from exacerbating local inflammation, TNF- can activate the NF-KB and MAPK signaling pathways, increasing cellular susceptibility to oxidative stress and weakening GPX4 and other antioxidant enzymes, thereby promoting further accumulation of lipid peroxidation byproducts and markedly elevating ferroptosis risk (119)

9.4 GSH-mediated immunotherapy Cancer immunotherapies, such as vaccines and immune checkpoint inhibitors, are most effective when their activity is confined to tumor sites

Apr 2006;45(4):370-374

Age: Glutathione levels naturally decrease with age, which can impair detoxification, immunity, and antioxidant protection

Citations Citations to this article as recorded by A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes E