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The main protease (M pro ), or 3C-like protease (3CL pro ), is an extremely important protease in the propagation of other coronaviruses, such as Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which is responsible for the cleavage of protein precursors of the translated viral genome, resulting in a number of nonstructural proteins (NSPs), that assemble to form the viral replication-transcription enzyme complex NSPs

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Petyaev IM, Dovgalevsky PY, Chalyk NE, Klochkov VA, Kyle NH, Bashmakov YK

[60] Measurement of baseline and periodic serum bicarbonate is recommended during topiramate therapy and prior to surgery

Betaine ameliorates acute sever ulcerative colitis by inhibiting oxidative stress induced inflammatory pyroptosis