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The SURMOUNT-5 trial showed 20.2% vs 13.7% weight loss, and Second Natures real-world data showed 22.1% vs 17.1%

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NAD + also plays an important role in DNA repair, serving as a substrate for poly-(ADP-ribose) polymerase (PARP) enzymes that are involved in the response to DNA damage (127130)

"Even with today's best medicines, metabolic surgery offers unique and lasting benefits for people with obesity and diabetes," said Ali Aminian, M.D., director of Cleveland Clinic's Bariatric & Metabolic Institute and primary investigator of the study