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GoldhaberSHeitJSharmaGNagelJSKimDParkerJAet alRandomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism

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Increasing too quickly, eating too little, skipping protein, or not staying hydrated can make treatment harder to tolerate

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Like a delicate piece of machinery, its effectiveness is entirely dependent on its three-dimensional structure remaining intact