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34 The authors showed that the exposure of the isolated enzyme to the oxidant ONOO leads to a disruption of the zincthiolate cluster, resulting in an uncoupling of the enzyme

Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]

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These four categories were built using a rule-based, ML-assisted classification model

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