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For maximum benefits, should be administered weekly

For example, naproxen and ketoprofen, which bind within the hydrophobic pocket close to Trp-213, result in greater fluorescence quenching than ibuprofen and diazepam which bind away from Trp-213 [74,75,76]

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Autotomy that occurs long after injury may appear as pain that occurs below the level of the injury (below-level pain) [64, 65], and the late spontaneous worsening may be the result of complete deafferentation of one or several spinal segments the stimulation of the nerve plexus, or dorsal root injury [66]