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Several studies in murine models have demonstrated that DZN disrupts the activity of antioxidant enzymes, particularly glutathione peroxidase, which plays a critical role in renal metabolism [43]

Parkinsons disease: mechanisms and models

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Our preliminary experiments showed that BPC157 protects cells from hydrogen peroxide-induced oxidative damage (Supplementary Figure S3A), suggesting antioxidant activity

This may explain why we could not detect ROS activated S1981 phosphorylation of ATM, particularly if the H 2 O 2 concentrations were not high enough to induce DNA damage in HFMs