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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

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Retatrutide achieved approximately 24 to 28.7% weight loss at its highest dose over 48 to 72 weeks, compared to Mounjaro achieving approximately 20 to 22.5% at its highest dose over 72 weeks

As noted in the CY 2026 PFS proposed rule (90 FR 32595), we believe these measures align with the goals of ASM and reflect meaningful use of CEHRT