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Upon binding its receptors in the gut, CCK induces contractions of the gallbladder and release of pancreatic enzymes and also inhibits gastric emptying

The Guardian also reported on Phase 3 trial results showing substantial average weight loss among adults with obesity or overweight, while noting common gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation

Even though semaglutide is the active drug in both cases, Wegovy is not approved to treat patients with type 2 diabetes

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However, the dosing and pharmacokinetics are designed so that both receptors receive clinically meaningful activation