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The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]

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doi: 10.1024/0300-9831/a000634

FOXO4-DRI + Thymalin Explored for synergistic effects on immune modulation and cellular aging