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In the oxidized state with two nearby cysteines forming a disulfide bond and the third cysteine unmodified, HMGB1 acts as a proinflammatory cytokine (Yang et al., 2021) which can interact with TLR4 (Pauletti et al., 2019)

Molecular Basis of Local Action The local effect of AOD 9604 injection is closely related to its molecular properties: Receptor specificity AOD 9604 has a high affinity for 3-AR and reduces systemic side effects